Title of article
Microwave-induced by-products in the synthesis of 2-(4-methyl-2-phenylpiperazinyl)pyridine-3-carbonitrile
Author/Authors
Lamazzi، نويسنده , , Christelle and Dreau، نويسنده , , Armelle and Bufferne، نويسنده , , Christel and Flouzat، نويسنده , , Christine and Carlier، نويسنده , , Patrick and ter Halle، نويسنده , , Rob and Besson، نويسنده , , Thierry، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
4502
To page
4505
Abstract
The Letter describes the investigation of an industrial reaction of N-methylphenylpiperazine and chloronicotinonitrile, under microwave heating. Besides the formation of the expected 2-(4-methyl-2-phenylpiperazinyl)pyridine-3-carbonitrile (4), extension of the scale leads to unexpected by-products. A specific pathway due to the formation of a reactive ‘ionic alkylating intermediate’ formed in situ under microwave conditions is proposed to explain the results observed.
Keywords
Piperazinoazepine derivatives , Piperazines , microwave irradiation
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1865218
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