Author/Authors :
Hong، نويسنده , , Sam Y. and Nandurdikar، نويسنده , , Rahul S. and Keefer، نويسنده , , Larry K. and Saavedra، نويسنده , , Joseph E. and Chakrapani، نويسنده , , Harinath، نويسنده ,
Abstract :
An improved synthesis of V-PROLI/NO, a cytochrome P450-activated nitric oxide (NO) prodrug, in an overall yield of 26% in four steps from prolinol is reported; the previously published yield of this transformation was 1%. Using this revised strategy, the sarcosine analogue (14) of V-PROLI/NO was prepared. Finally, the methyl ester of V-PROLI/NO (15) was found to be an esterase-activated prodrug form of V-PROLI/NO.
