Title of article
Direct reductive aminations with catalytic molybdenum dioxide dichloride and phenylsilane
Author/Authors
Smith، نويسنده , , Clive A. and Cross، نويسنده , , Laura E. and Hughes، نويسنده , , Kimberley and Davis، نويسنده , , Rebecca E. and Judd، نويسنده , , Duncan B. and Merritt، نويسنده , , Andrew T.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
6
From page
4906
To page
4911
Abstract
A powerful direct reductive amination (DRA) method is developed, using catalytic MoO2Cl2 and phenylsilane (PhSiH3) as the reducing agent. The alkylation of a range of amines (pKa 0–7.8) with both an electron-deficient and two electron-rich-aldehydes is achieved in good to excellent yields. The novel employment of this DRA in alcoholic solvents significantly improves the reaction scope and excellent functional group selectivity is exhibited.
Keywords
Direct reductive amination (DRA) , Molybdenum dioxide dichloride , Phenylsilane , Sodium triacetoxyborohydride , Aryl PFP-sulfonate esters
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1865510
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