Title of article
Generation of novel, potent urotensin-II receptor antagonists by alkylation–cyclization of isoindolinone C3-carbanions
Author/Authors
Luci، نويسنده , , Diane K. and Lawson، نويسنده , , Edward C. and Ghosh، نويسنده , , Shyamali and Kinney، نويسنده , , William A. and Smith، نويسنده , , Charles E. and Qi، نويسنده , , Jenson and Wang، نويسنده , , Yuanping and Minor، نويسنده , , Lisa K. and Maryanoff، نويسنده , , Bruce E.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
4958
To page
4961
Abstract
We report a facile alkylation–cyclization reaction involving the isoindolinone C3 position, which resulted in tricyclic derivatives 2 and 10 in 48% and 32% yields, respectively. These novel compounds possess potent urotensin-II receptor antagonist activity.
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1865541
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