Author/Authors :
Luci، نويسنده , , Diane K. and Lawson، نويسنده , , Edward C. and Ghosh، نويسنده , , Shyamali and Kinney، نويسنده , , William A. and Smith، نويسنده , , Charles E. and Qi، نويسنده , , Jenson and Wang، نويسنده , , Yuanping and Minor، نويسنده , , Lisa K. and Maryanoff، نويسنده , , Bruce E.، نويسنده ,
Abstract :
We report a facile alkylation–cyclization reaction involving the isoindolinone C3 position, which resulted in tricyclic derivatives 2 and 10 in 48% and 32% yields, respectively. These novel compounds possess potent urotensin-II receptor antagonist activity.
