An efficient synthetic route for quinazolinyl 4-thiazolidinones

An efficient solvent-free cyclocondensation route for condensing mercaptoacetic acid with quinazolinyl-substituted azomethines has been developed using silica chloride as a catalyst for obtaining heteryl-substituted 4-thiazolidinones. The route is found to be rapid, relatively economical, and eco-friendly. The precursors, quinazolinyl azomethines have been obtained in multisteps starting from quinazolinone.