Title of article
Synthesis of the new ring system 6,8-dihydro-5H-pyrrolo[3,4-h]quinazoline
Author/Authors
Barraja، نويسنده , , Paola and Spanٍ، نويسنده , , Virginia and Diana، نويسنده , , Patrizia and Carbone، نويسنده , , Anna and Cirrincione، نويسنده , , Girolamo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
5389
To page
5391
Abstract
A convenient synthesis of the pyrrolo[3,4-h]quinazoline ring system is reported. Our synthetic approach consisted of the annelation of a pyrimidine ring to an isoindole moiety using tetrahydroisoindole-4-ones as building blocks. The antiproliferative activity of the new compounds was investigated and one of them showed antitumor activity against all the 59 tested cell lines at micromolar concentrations (1.46–18.4 μM).
Keywords
4-h]quinazolines , Antiproliferative activity , Isoindole building blocks , Pyrimidine annelation
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1865856
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