Author/Authors :
Horne، نويسنده , , Daniel B. and Bartberger، نويسنده , , Michael D. and Kaller، نويسنده , , Matthew R. and Monenschein، نويسنده , , Holger and Zhong، نويسنده , , Wenge and Hitchcock، نويسنده , , Stephen A.، نويسنده ,
Abstract :
We report the efficient synthesis of difluoroalkyl aryl ethers from the rearrangement of heteroaryl ketones and aldehydes, mediated by xenon difluoride and HF/pyridine in methylene chloride at room temperature. Computational analysis of difluoroalkylethers shows that there is potential to allow access to conformational space not accessible to the hydrogenated parent.
