Title of article
The first chemical synthesis of F-4-GlcAβ(1→3)GlcNAc-UDP with the potential of novel substrate and enzyme inhibitor for hyaluronic acid synthases (HASs)
Author/Authors
Wei، نويسنده , , Guohua and Kumar، نويسنده , , Vipin and Xue، نويسنده , , Jun and Locke، نويسنده , , Robert D. and Matta، نويسنده , , Khushi L. Matta، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
5920
To page
5922
Abstract
The first chemical synthesis of F-4-GlcAβ(1→3)GlcNAc-UDP is described here. This compound can serve as a novel substrate to study the catalytic mechanism of hyaluronic acid synthases (HASs) and has potential to be donor for these enzymes that extend HA chain at the reducing end. Moreover, it may also behave as inhibitor for the enzymes that act on non-reducing end in the assembly of HA chain.
Keywords
phosphates , F-4-GlcA , oligosaccharides , Hyaluronic acid synthases (HASs)
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1866222
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