Title of article
BF3·OEt2-promoted reaction of isocyanides with o-aminobenzophenones
Author/Authors
Krasavin، نويسنده , , Mikhail and Busel، نويسنده , , Alina and Parchinsky، نويسنده , , Vladislav، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
6
From page
5945
To page
5950
Abstract
Aliphatic isocyanides react with o-aminobenzophenones in dichloromethane under Lewis acid catalysis at ambient temperature to give, unexpectedly, 4-aryl-4-hydroxy-3,4-dihydroquinazolines in good to excellent yields. The outcome of the reaction is rationalized by a skeletal rearrangement of the initially formed ‘intramolecular Passerini’ reaction products, 2-amino-3-hydroxy-3-aryl-3H-indoles.
Keywords
Isocyanide-based multicomponent reactions , Bifunctional reagents , Lewis acid catalysis , skeletal rearrangement
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1866238
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