An efficient synthesis of (R)- and (S)-baclofen via desymmetrization
Author/Authors :
Ji، نويسنده , , Lei and Ma، نويسنده , , Yuheng and Li، نويسنده , , Jin and Zhang، نويسنده , , Liangren and Zhang، نويسنده , , Lihe، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Pages :
3
From page :
6166
To page :
6168
Abstract :
A short and highly enantioselective synthesis of both enantiomers of GABA agonist baclofen in four steps with total yields of 32.8% [for (S)-isomer] and 35.1% [for (R)-isomer] is reported. The key step involved desymmetrization of cyclic anhydride with modified cinchona alkaloids.
