Author/Authors :
Chang، نويسنده , , Ronald K. and Di Marco، نويسنده , , Christina N. and Pitts، نويسنده , , Daniel R. and Greshock، نويسنده , , Thomas J. and Kuduk، نويسنده , , Scott D.، نويسنده ,
Abstract :
The scope and limitations of SNAr substitution reactions of metalated 4-cyanopiperidines with heterocyclic halides were explored. These facile reactions provide rapid access to a wide range of 4-heteroaryl-4-cyanopiperidines and have resulted in improved yields, faster reaction times, and lower temperatures than previously published synthetic methods.
