Author/Authors :
Ivana Kosiova، نويسنده , , Ivana and To??k، نويسنده , , Zden?k and Bud???nsk?، نويسنده , , Milo? and ?im?k، نويسنده , , Ond?ej and Liboska، نويسنده , , Radek and Rejman، نويسنده , , Dominik and Pa?es، نويسنده , , Ond?ej and Rosenberg، نويسنده , , Ivan، نويسنده ,
Abstract :
A straightforward procedure leading to the new phosphonylating reagent, methyl 4-toluenesulfonyloxymethylphosphonate, requiring no chromatographic purification is described. This stable reagent works with the same efficiency as dimethyl and other dialkyl esters for the introduction of an O-phosphonomethyl moiety while, in contrast to dimethyl ester, it does not cause any unwanted methylation of sensitive functionalities. Its utility for the alkylation of protected nucleosides in high yield is exemplified.
