Author/Authors :
Laval، نويسنده , , Stéphane and Dayoub، نويسنده , , Wissam and Favre-Réguillon، نويسنده , , Alain and Berthod، نويسنده , , Mikaël and Demonchaux، نويسنده , , Patrice and Mignani، نويسنده , , Gérard and Lemaire، نويسنده , , Marc، نويسنده ,
Abstract :
A simple and useful method for the reduction of nitriles into the corresponding amines using a tetramethyldisiloxane/titanium(IV) isopropoxide reducing system is described. The synthetic approach is straightforward and provides primary amines as hydrochloride salt in almost quantitative yield. Other advantages of this method, such as easy-to-handle hydride source, inert by-products, that is, TiO2 and oligomeric siloxanes, make it very attractive to prepare primary amines.
Keywords :
Nitriles , Reduction , Titanium , Amines , Tetramethyldisiloxane
