Author/Authors :
Metzger، نويسنده , , Axel and Qin، نويسنده , , Lan-Ying and Cole، نويسنده , , Andrew G. and Saionz، نويسنده , , Kurt W. and Brescia، نويسنده , , Marc-Raleigh and Gstach، نويسنده , , Hubert and Wareing، نويسنده , , James R. and Zimmermann، نويسنده , , Juerg and Brill، نويسنده , , Wolfgang K-D. and Baldwin، نويسنده , , John J. and Dolle، نويسنده , , Roland E. and Henderson، نويسنده , , Ian، نويسنده ,
Abstract :
An efficient and general synthesis of substituted 2-amino-7,8-dihydropteridin-6(5H)-ones using a combination of solution-phase and solid-phase chemistry is described. Solution-phase chemistry was used to produce two pyrimidine regioisomers that were separated by flash column chromatography. Utilizing the desired regioisomer, solid-phase chemistry was used to effect the rapid construction of the substituted 2-amino-7,8-dihydropteridin-6(5H)-one system in high overall yield and purity.
