Title of article :
Synthesis of 4,5-disubstituted-3-trihalomethylisothiazoles
Author/Authors :
Zawistoski، نويسنده , , Michael P. and Decker، نويسنده , , Shannon M. and Griffith، نويسنده , , David A.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
Herein, we describe the synthesis of 4,5-disubstituted-3-trihalomethylisothiazoles from trihaloacetonitriles and 2-cyanothioacetamides or 2-ethoxycarbonylthioacetamides. The reactivity of the necessary trihaloacetonitriles has a significant impact on the observed reaction pathways. Reactions with CF3CN require an oxidant to mediate cyclization, while CCl3CN functions as both the reactant and oxidant.
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
