Title of article
Conversion of pravastatin into an advanced intermediate for the synthesis of the HMG-CoA reductase inhibitor BB-476
Author/Authors
Cronje Grove، نويسنده , , J.J. and van Heerden، نويسنده , , Pieter S. and Ferreira، نويسنده , , Daneel and Bezuidenhoudt، نويسنده , , Barend C.B.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
3
From page
57
To page
59
Abstract
Rearrangement of the decalin system of pravastatin under SN2′ Mitsunobu conditions and subsequent selective hydrolysis and oxidation afforded a key dienone 23, which upon copper-catalyzed addition of a 1E-propenyl moiety established the carbon framework of BB-476 3 in high diastereomeric excess.
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1870454
Link To Document