Title of article :
Electrophilic fluorination: the aminopyridine dilemma
Author/Authors :
Fields، نويسنده , , Stephen C. and Lo، نويسنده , , William C. and Brewster، نويسنده , , William K. and Lowe، نويسنده , , Christian T.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2010
Abstract :
An unusually high yielding fluorination of aminopyralid (3) using F-TEDA (SELECTFLUOR™) in warm water, followed by kinetic resolution (via iterative esterification/saponification) of the crude fluorination product with dry HCl in methanol produced pure ring-fluorinated pyridine 2 in an overall yield of 31% for the two steps.
Keywords :
Electrophilic fluorination , Aminopyridine , F-TEDA
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
