Title of article
Comparative toxicity of [3]ferrocenophane and ferrocene moieties on breast cancer cells
Author/Authors
Gormen، نويسنده , , Meral and Pla?uk، نويسنده , , Damian and Pigeon، نويسنده , , Pascal and Hillard، نويسنده , , Elizabeth A. and Plamont، نويسنده , , Marie-Aude and Top، نويسنده , , Siden and Vessières، نويسنده , , Anne and Jaouen، نويسنده , , Gérard، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
3
From page
118
To page
120
Abstract
Recent results suggest that [3]ferrocenophane may be an interesting motif in the development of cytotoxic anti-cancer agents. We here report the synthesis of three such compounds based on the 1-[(p-R-phenyl)-phenyl-methylidenyl)]-[3]ferrocenophane skeleton with R = OH, NH2 and NHC(O)CH3 substitution on one of the phenyl rings. Cytotoxicity studies show that these compounds are up to four times more powerful against hormone-independent breast cancer cells than their corresponding ferrocene analogs.
Keywords
cytotoxicity , breast cancer , Bioorganometallic , Ferrocenophane
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1870503
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