Title of article
Substrate specificity of the CYC2 enzyme from Kitasatospora griseola: production of sclarene, biformene, and novel bicyclic diterpenes by the enzymatic reactions of labdane- and halimane-type diterpene diphosphates
Author/Authors
Nakano، نويسنده , , Chiaki and Hoshino، نويسنده , , Tsutomu and Sato، نويسنده , , Tsutomu and Toyomasu، نويسنده , , Tomonobu and Dairi، نويسنده , , Tohru and Sassa، نويسنده , , Takeshi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
125
To page
128
Abstract
The enzymatic reaction of copalyl diphosphate (CDP), ent-CDP, syn-CDP, and tuberculosinyl diphosphate with the CYC2 enzyme from Kitasatospora griseola afforded sclarene, biformene, and novel diterpenes having a buta-1,3-diene moiety in the side chain. The substrate specificity of the CYC2 is discussed.
Keywords
Diterpenes , Enzymatic synthesis , Sclarene , Biformene , Unnatural natural product
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1870510
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