Title of article
Structure, biological activity, and a biomimetic partial synthesis of the lirofolines, novel pentacylic indole alkaloids from Tabernaemontana
Author/Authors
Low، نويسنده , , Yun-Yee and Lim، نويسنده , , Kuan-Hon and Choo، نويسنده , , Yeun-Mun and Pang، نويسنده , , Huey-Shen and Etoh، نويسنده , , Tadahiro and Hayashi، نويسنده , , Masahiko and Komiyama، نويسنده , , Kanki and Kam، نويسنده , , Toh-Seok، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
269
To page
272
Abstract
Two new pentacyclic indole alkaloids, lirofolines A and B, possessing a novel rearranged ibogan ring system, are obtained from two Malayan Tabernaemontana species (Tabernaemontana corymbosa and Tabernaemontana divaricata) and the structures are established by analysis of the spectroscopic data. A biomimetic partial synthesis of lirofoline A from ibogaine via the Polonovski reaction is carried out. Lirofolines A and B showed significant activity in reversing multidrug resistance in vincristine-resistant KB cells (IC50 3.4 and 7.5 μg/ml, respectively).
Keywords
Alkaloids , NMR , Partial synthesis , biological activity , Tabernaemontana
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1870605
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