Author/Authors :
Wu، نويسنده , , Lisa Y. and Choi، نويسنده , , Joseph K. and Hatton، نويسنده , , Krit Y. and Berkman، نويسنده , , Clifford E.، نويسنده ,
Abstract :
Magnesium bis(monoperoxyphthalate) hexahydrate (MMPP) was found to be an effective reagent for the oxidation of various α-amino acid esters to the corresponding α-oximino acid esters. This transformation could be completed under mild conditions within 2.5 h using 1.1 equiv of MMPP in THF. Clean oximino esters were obtained after quenching and extracting the reaction from sodium thiosulfate solution. The O-phosphorylated derivative of 2-oximinoglutarate exhibited slow binding inhibitory potency for the metallopeptidase prostate-specific membrane antigen (PSMA) with an IC50 value of 58 nM.
