Title of article
Concise route to the key intermediate for divergent synthesis of C7-substituted fluoroquinolone derivatives
Author/Authors
Zhang، نويسنده , , Xin and Mu، نويسنده , , Feng and Robinson، نويسنده , , Bobby and Wang، نويسنده , , Pengfei، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
2
From page
600
To page
601
Abstract
A concise route to ethyl 7-bromo-1-cyclopropyl-6,8-difluoro-4-quinolone-3-carboxylate has been developed. This compound is a key intermediate for divergent synthesis of various C7-substituted fluoroquinolones, a group of potent topoisomerase II inhibitors with promising clinical applications.
Keywords
Fluorquinolone , antibiotics , Topoisomerase II inhibitor , Cancer drug
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1870831
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