Title of article
A general route to 5-substituted-2-furylacetic acids: a brief synthesis of plakorsin B
Author/Authors
Hayes، نويسنده , , Simon J. and Knight، نويسنده , , David W. and Smith، نويسنده , , Andrew W.T. and O’Halloran، نويسنده , , Mark J.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
3
From page
717
To page
719
Abstract
3,4-Dihydroxy-5-alkynylcarboxylic acids, readily obtained by the addition of lithium acetylides to α-acetoxysuccinic anhydride followed by reduction and hydrolysis, undergo smooth silver(I)-catalysed 5-endo-dig cyclisations and in situ dehydration to give excellent overall yields of 5-substituted-2-furylacetic acids, including the natural metabolite plakorsin B.
Keywords
Silver-catalysed , furan , 5-endo-dig , Plakorsin , 2-Furylacetic acids
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1870924
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