Parallel synthesis enablement of 2-pyridyl-5-cyano-pyrimidine-6-ones—a novel class of HIF-hydroxylase inhibitors
Author/Authors :
Chang، نويسنده , , Shang-Poa and Hungerford، نويسنده , , William M. and McDonald، نويسنده , , Wayne S. and Maguire، نويسنده , , Robert J. and Malony، نويسنده , , Kelly Q. and Subramanyam، نويسنده , , Chakrapani، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2010
Pages :
3
From page :
952
To page :
954
Abstract :
The synthesis of various substituted 2-pyridyl-5-cyano-pyrimidine-6-ones was accomplished via a three-step protocol. The key aspects of this parallel protocol was the preparation of amidines from nitriles under mild conditions followed by cyclization with ethyl (ethoxymethylene)cyanoacetate.
