Title of article
Design and synthesis of indole derivatives of adenophostin A. A entry into subtype-selective IP3 receptor ligands
Author/Authors
Mochizuki، نويسنده , , Tetsuya and Tanimura، نويسنده , , Akihiko and Nezu، نويسنده , , Akihiro and Ito، نويسنده , , Mika and Abe، نويسنده , , Hiroshi and Ito، نويسنده , , Yoshihiro and Arisawa، نويسنده , , Mitsuhiro and Shuto، نويسنده , , Satoshi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
3
From page
977
To page
979
Abstract
Indole derivatives 3a and 3b of adenophostin A (2) in which the adenine of 2 was replaced with indole or 4-fluoroindole was designed as potential inositol trisphosphate receptor ligands. These target compounds were successfully synthesized from the key disaccharide unit 6. Biological evaluation showed that 3b selectively activates IP3R1, a subtype of IP3 receptors.
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1871113
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