Title of article
One-pot N-dealkylation and acid-catalyzed rearrangement of morphinans into aporphines
Author/Authors
Berényi، نويسنده , , Sلndor and Gyulai، نويسنده , , Zsuzsanna and Udvardy، نويسنده , , Antal and Sipos، نويسنده , , Attila، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
3
From page
1196
To page
1198
Abstract
The one-pot N-demethylation and acid-catalyzed rearrangement of morphinan-N-oxides offers a new, shorter and more efficient route to neuropharmacologically important N-substituted aporphines. An improved procedure is described for the preparation of the starting alkaloid N-oxides using Na2WO4 as catalyst. The transetherification during the rearrangement of codeinone into 2-O-alkyl-norapocodeines is documented.
Keywords
Dopaminergic , Morphinans , Acid-catalyzed rearrangement , N-Dealkylation , Aporphines
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1871261
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