Title of article
Facile transformation of glutamic acid into proline residue inside a tripeptide backbone
Author/Authors
Mollica، نويسنده , , Adriano and Stefanucci، نويسنده , , Azzurra and Feliciani، نويسنده , , Federica and Torino، نويسنده , , Domenica and Cacciatore، نويسنده , , Ivana and Pinnen، نويسنده , , Francesco and Lucente، نويسنده , , Gino، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
3
From page
1333
To page
1335
Abstract
In this Letter we present a simple reaction pathway which allows the conversion of the glutamic acid residue of a tripeptide into a proline residue. The reaction was performed by using Boc-Val-Glu-Phe-NH2 as a starting material and is based on a NaH-induced intraresidue alkylation under reaction conditions analogous to that adopted during the Freidinger lactams formation.
Keywords
?-Lactam-constrained peptides , Glutamic Acid , proline , Peptides
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1871363
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