Author/Authors :
Gallou، نويسنده , , Fabrice and Han، نويسنده , , Bo and Lu، نويسنده , , Jiang and Seeger-Weibel، نويسنده , , Manuela and Stoessel، نويسنده , , Anne-Florence and Allmendinger، نويسنده , , Simon، نويسنده ,
Abstract :
A selective and practical approach for the formation of cis-1,4-aminocyclohexanol was developed. The key transformation involves a one-pot imine formation/ Lewis acid-directed imine reduction and results in a highly selective attack of the reducing agent. This simple and practical method is easily amenable to large-scale synthesis.
Keywords :
4-Aminocyclohexanol , reductive amination , Selectivity , cis-1
