Title of article
Desymmetrisation of (4R,5S)-4,5-diphenylimidazolidine-2-thione using pentafluorophenyl active esters
Author/Authors
Andreou، نويسنده , , Anna and Eames، نويسنده , , Jason and Motevalli، نويسنده , , Majid and Prior، نويسنده , , Timothy J. and Watkinson، نويسنده , , Michael، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
3
From page
1423
To page
1425
Abstract
(4R,5S)-4,5-Diphenylimidazolidine-2-thione is efficiently desymmetrised by stereorandom deprotonation with NaHMDS, followed by kinetic resolution of the resulting racemic intermediate with an enantiomerically pure pentafluorophenyl active ester. The levels of diastereocontrol were found to be excellent (86–92% de at ∼30% conversion). This desymmetrisation reaction is an example of a masked resolution.
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1871414
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