Author/Authors :
Das، نويسنده , , Bhaskar C. and Mahalingam، نويسنده , , Sakkarapalayam M. and Panda، نويسنده , , Lipsa and Wang، نويسنده , , Bo and Campbell، نويسنده , , Phillp D. and Evans، نويسنده , , Todd، نويسنده ,
Abstract :
Novel retinoids 1–3 containing perillyl alcohol were synthesized through the addition of perillyl alcohol to the activated carboxylic acids (retinoids) promoted by DCC (N,N′-dicyclohexyl carbodiimide). A set of structurally and functionally diverse perillyl alcohol derivatives of retinoids were obtained in good yields (78–82%). Biological evaluation of these novel hybrid compounds (containing retinoids and perillyl alcohol) is currently underway in our laboratory.
