A new method for cleavage of silicon–carbon linkers on glass plate supports with applications to solid-phase syntheses on silica resins

We describe herein a novel and facile method for the cleavage of a silicon-based linker on solid-phase supports such as glass plates or silica resin. The linker was efficiently cleaved by oxidation of the silicon–carbon bond (Tamao–Kumada oxidation) to release the functionalized molecule.