Author/Authors :
Hazra، نويسنده , , Abhijit and Paira، نويسنده , , Priyankar and Sahu، نويسنده , , Krishnendu B. and Naskar، نويسنده , , Subhendu and Saha، نويسنده , , Pritam and Paira، نويسنده , , Rupankar and Mondal، نويسنده , , Shyamal and Maity، نويسنده , , Arindam and Luger، نويسنده , , Peter and Weber، نويسنده , , Manuela and Mondal، نويسنده , , Nirup B. and Banerjee، نويسنده , , Sukdeb، نويسنده ,
Abstract :
A facile synthesis of novel di-spiro compounds has been achieved via 1,3-dipolar cycloaddition of azomethine ylides generated in situ from isatin derivatives and sarcosine to the conjugated double bond of andrographolide. When the amino acid was changed from sarcosine to l-proline, the product formation took a different course as determined by 2D NMR and X-ray crystallographic analysis.
Keywords :
Azomethine ylide , Dispiro-oxindole , 2D NMR , dipolar cycloaddition , Andrographolide
