Title of article :
Chemical synthesis of Ser/Thr AMPylated peptides
Author/Authors :
Yasmin A. Al-Eryani، نويسنده , , Rwaida A. and Li، نويسنده , , Yan and Ball، نويسنده , , Haydn L. Ball، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2010
Abstract :
A method for the solid phase chemical synthesis of AMPylated Ser/Thr containing peptides is described. Peptides were phosphonylated using the H-phosphonate method, then the adenosine moiety was introduced using 2′,3′-isopropylidene adenosine and the condensing reagent PyBOP. Oxidation with iodine yielded the desired AMPylated product in good yield following acidolytic cleavage from the resin support.
Keywords :
H-phosphonate , Bis(diethylamino) chlorophosphine , Benzotriazole-1-yl oxy-tris-pyrrolidino-phosphonium hexafluorophosphate (PyBOP) , AMP , SPPS , AMPylation , 2? , 3?-Isopropylidene adenosine
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
