Title of article
Chemical synthesis of Ser/Thr AMPylated peptides
Author/Authors
Yasmin A. Al-Eryani، نويسنده , , Rwaida A. and Li، نويسنده , , Yan and Ball، نويسنده , , Haydn L. Ball، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
2
From page
1730
To page
1731
Abstract
A method for the solid phase chemical synthesis of AMPylated Ser/Thr containing peptides is described. Peptides were phosphonylated using the H-phosphonate method, then the adenosine moiety was introduced using 2′,3′-isopropylidene adenosine and the condensing reagent PyBOP. Oxidation with iodine yielded the desired AMPylated product in good yield following acidolytic cleavage from the resin support.
Keywords
H-phosphonate , Bis(diethylamino) chlorophosphine , Benzotriazole-1-yl oxy-tris-pyrrolidino-phosphonium hexafluorophosphate (PyBOP) , AMP , SPPS , AMPylation , 2? , 3?-Isopropylidene adenosine
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1871600
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