Title of article
Copper–bipyridine-catalyzed enantioselective α-amination of β-keto esters
Author/Authors
Ghosh، نويسنده , , Subrata and Nandakumar، نويسنده , , Mecheril Valsan and Krautscheid، نويسنده , , Harald Jorn Schneider، نويسنده , , Christoph، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
3
From page
1860
To page
1862
Abstract
The Cu(OTf)2-bipyridine-catalyzed, enantioselective, direct α-amination of β-keto esters and β-diketones with diethyl azodicarboxylate (DEAD) has been studied. Exceptionally high enantioselectivities of up to 99% ee were found for 1-indanone-based β-keto esters in particular even for substrates and reagents carrying conventional ester groups such as methyl and ethyl.
Keywords
Asymmetric catalysis , amination , ?-Ketoester , Copper(II)-catalyzed , bipyridine , Diethyl azodicarboxylate
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1871664
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