Author/Authors :
Tsuboi، نويسنده , , Kazuma and Nakamura، نويسنده , , Tomoaki and Suzuki، نويسنده , , Takahiro and Nakazaki، نويسنده , , Atsuo and Kobayashi، نويسنده , , Susumu، نويسنده ,
Abstract :
A second-generation total synthesis of (−)-diversifolin has been achieved by a more straightforward strategy, involving a highly stereochemistry-dependent 10-membered ring-closing metathesis and a stereoselective dihydroxylation/lactone transposition sequence. Compared to our previous synthesis, the present synthesis is improved in the yield of the key intermediate 2 (20% in 12 steps from diol 8).
