Title of article
Microwave-accelerated fluorodenitrations and nitrodehalogenations: expeditious routes to labeled PET ligands and fluoropharmaceuticals
Author/Authors
Paul LaBeaume، نويسنده , , Paul and Placzek، نويسنده , , Michael and Daniels، نويسنده , , Mathew and Kendrick، نويسنده , , Ian and Ng، نويسنده , , Patrick and McNeel، نويسنده , , Melissa and Afroze، نويسنده , , Roushan and Alexander، نويسنده , , Abigail and Thomas، نويسنده , , Rhiannon and Kallmerten، نويسنده , , Amy E. and Jones، نويسنده , , Graham B.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
1906
To page
1909
Abstract
Methods for the expeditious fluorination of arenes have been investigated, using readily available fluoride sources. An optimized procedure for microwave-accelerated fluorodenitration has been developed, giving good to excellent yields in less than 10 min, rendering it practical for use in the preparation of F18 labeled ligands for PET imaging. Application of the method in the synthesis of CNS agents is demonstrated, and a practical method for the preparation of substrates is also presented.
Keywords
Nitrodehalogenation , PET , donepezil , Haloperidol , Fluorodenitration , F18 , microwave
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1871819
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