Author/Authors :
Fujino، نويسنده , , Tomoko and Tsunaka، نويسنده , , Nobuhide and Guillot-Nieckowski، نويسنده , , Marine and Nakanishi، نويسنده , , Waka and Iwamoto، نويسنده , , Takeaki and Nakamura، نويسنده , , Eiichi and Isobe، نويسنده , , Hiroyuki، نويسنده ,
Abstract :
Deoxyribonucleoside analogues bearing acetylene group at the pseudo-5′-position and azido group at the pseudo-3′-position have been synthesized by transglycosylation reaction of deoxythymidine analogue with adenine, cytosine, and guanine nucleobases as nucleophiles. The structures of analogues were studied in crystalline state by X-ray crystallography as well as in solution phase by NMR spectroscopy and showed the puckering conformations similar to the natural congeners.
