Author/Authors :
Wu، نويسنده , , Yong-Jin and Huang، نويسنده , , Stella and Ng، نويسنده , , Alicia and Gao، نويسنده , , Qi and Roy Kimura، نويسنده , , S. and Langley، نويسنده , , David R.، نويسنده ,
Abstract :
Direct oximation of 2-oxo-2-phenylacetate (3) gave the (Z)-methyl 2-(methoxyimino)-2-phenylacetate (1) in 71% yield, while the E oxime 2 was prepared from 3 in 65% yield via oxime isomerization of 2-(methoxyimino)-2-phenylacetic acid (5). Computational studies suggest that the isomerization of 5 is thermodynamically driven, while the direct oximation of ketoester 3 is kinetically controlled.
