Title of article
Efficient synthesis of (Z)- and (E)-methyl 2-(methoxyimino)-2-phenylacetate
Author/Authors
Wu، نويسنده , , Yong-Jin and Huang، نويسنده , , Stella and Ng، نويسنده , , Alicia and Gao، نويسنده , , Qi and Roy Kimura، نويسنده , , S. and Langley، نويسنده , , David R.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
2144
To page
2147
Abstract
Direct oximation of 2-oxo-2-phenylacetate (3) gave the (Z)-methyl 2-(methoxyimino)-2-phenylacetate (1) in 71% yield, while the E oxime 2 was prepared from 3 in 65% yield via oxime isomerization of 2-(methoxyimino)-2-phenylacetic acid (5). Computational studies suggest that the isomerization of 5 is thermodynamically driven, while the direct oximation of ketoester 3 is kinetically controlled.
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1871969
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