Title of article
Preparation of a water-soluble fluorinated zinc phthalocyanine and its effect for photodynamic therapy
Author/Authors
Oda، نويسنده , , Kazuo and Ogura، نويسنده , , Shun-ichiro and Okura، نويسنده , , Ichiro، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
6
From page
20
To page
25
Abstract
An amphiphilic fluorinated phthalocyanine, zinc tetracarboxyoctafluorophthalocyanine (ZnC4F8Pc) was synthesized and characterized. Its photodynamic efficiency for HeLa cells was compared with hydrophilic zinc octacarboxyphthalocyanine (ZnC8Pc) and hydrophobic zinc hexadecafluorophthalocyanine (ZnF16Pc). ZnC4F8Pc had a remarkable photodynamic effect among the phthalocyanines used. The effect is apparently caused by the fact that ZnC4F8Pc is mainly accumulated in the hydrophobic lipid membrane and is in the photoactive monomer form in HeLa cells.
Keywords
Phthalocyanine , photodynamic therapy
Journal title
Journal of Photochemistry and Photobiology B:Biology
Serial Year
2000
Journal title
Journal of Photochemistry and Photobiology B:Biology
Record number
1871987
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