Author/Authors :
Best، نويسنده , , Daniel and Chairatana، نويسنده , , Phoom and Glawar، نويسنده , , Andreas F.G. and Crabtree، نويسنده , , Elizabeth and Butters، نويسنده , , Terry D. and Wilson، نويسنده , , Francis X. and Yu، نويسنده , , Chu-Yi and Wang، نويسنده , , Wu-Bao and Jia، نويسنده , , Yue-Mei and Adachi، نويسنده , , Isao and Kato، نويسنده , , Atsushi and Fleet، نويسنده , , George W.J.، نويسنده ,
Abstract :
2-Acetamido-1,2-dideoxy-d-galacto-nojirimycin [DGJNAc], prepared in 20% overall yield from d-glucuronolactone, is the first potent competitive sub-micromolar inhibitor of α-N-acetyl-galactosaminidases (Ki 0.081 μM from chicken liver, Ki 0.136 μM from Charonia lampas). DGJNAc is a good competitive—whereas the enantiomer l-DGJNAc is a very weak but non-competitive—inhibitor of β-hexosaminidases.
