Author/Authors :
Rodrigues، نويسنده , , Oscar E.D. and de Souza، نويسنده , , Diego and Soares، نويسنده , , Letiére C. and Dornelles، نويسنده , , Luciano and Burrow، نويسنده , , Robert A. and Appelt، نويسنده , , Helmoz R. and Alves، نويسنده , , Camila F. and Alves، نويسنده , , Diego and Braga، نويسنده , , Antonio L.، نويسنده ,
Abstract :
A stereoselective synthesis of selenosteroids 4 and 5 has been achieved. Starting from commercial available cholesterol 1, followed by asymmetric epoxidation, and subsequently, by stereoselective epoxide ring opening, employing a selenium nucleophilic species, the correspondent products were afforded in high yields. The compounds were being evaluated for their biological activity and as a chiral pool for asymmetric transformations.
