Author/Authors :
Legrand، نويسنده , , Sacha and Heikkinen، نويسنده , , Harri and Nicholls، نويسنده , , Ian A. and Root، نويسنده , , Andrew and Svenson، نويسنده , , Johan and Unelius، نويسنده , , C. Rikard، نويسنده ,
Abstract :
The preparation, characterization and application of a new stationary phase derived from 1,4-cyclohexanedione and diethyl (+)-tartrate are described. A suitable TADDOL for immobilization has been synthesized and grafted to a γ-mercaptopropylsilylated silica gel. The resulting modified stationary phase has been characterized and its ability to separate enantiomers has been studied. While the free TADDOL in solution was able to resolve a range of enantiomers, the resolving properties were lost on immobilization. Solid state 13C CPMAS NMR of the new stationary phase was used to explain the lack of stereoselective recognition.
