Title of article
Domino Knoevenagel–hetero-Diels–Alder reactions: a stereoselective synthesis of sugar-annulated furo[3,2-b] pyrano[4,3-d]pyran derivatives
Author/Authors
Yadav، نويسنده , , J.S. and Reddy، نويسنده , , B.V. Subba and Gopal، نويسنده , , A.V. Hara and Rao، نويسنده , , R. Nageshwar and Somaiah، نويسنده , , R. and Reddy، نويسنده , , P. Purushotham and Kunwar، نويسنده , , A.C.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
2305
To page
2308
Abstract
The O-propargyl derivative of a sugar aldehyde derived from d-glucose undergoes smooth intramolecular domino Knoevenagel–hetero-Diels–Alder reactions with 1,3-diketones in the presence of CuI/Et3N system in refluxing methanol to afford a novel class of carbohydrate analogues, furopyranopyrans in good yields. 1-Aryl-pyrazol-5-ones also undergo smooth coupling with O-propargyl tethered sugar aldehyde under similar conditions to furnish pyrazole-annulated furopyranopyrans. The stereochemistry of the products was assigned by various NMR experiments.
Keywords
3-diones , Pyrazolones , Polycyclic heterocycles , Domino Knoevenagel–hetero-Diels–Alder reaction , 1 , Sugar aldehyde
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1872058
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