Author/Authors :
Konakahara، نويسنده , , Takeo and Kiran، نويسنده , , Y.B. and Okuno، نويسنده , , Yuri and Ikeda، نويسنده , , Reiko and Sakai، نويسنده , , Norio، نويسنده ,
Abstract :
A simple and efficient total synthesis of ellipticine was developed via the Suzuki–Miyaura coupling of sterically sensitive 2-hydroxybenzeneboronic acid with a multifunctional aryl halide using Pd(OAc)2 as a catalyst and Cu(OAc)2·H2O as an additive in DMSO/H2O as a key step followed by double N-arylation and cyclization.
Keywords :
ellipticine , Suzuki–Miyaura coupling , Formylation , Steric sensitivity , Double N-arylation
