Author/Authors :
Sankar، نويسنده , , Arigala Uma Ravi and Yamasitha، نويسنده , , Mitsuji and Srinivasulu، نويسنده , , Kambam and Ozaki، نويسنده , , Nobuhisa and Aoki، نويسنده , , Takashi and Fujie، نويسنده , , Michio and Ogawa، نويسنده , , Keisuke and Okada، نويسنده , , Shingo and Yamada، نويسنده , , Manubu and Tanaka، نويسنده , , Yasutaka and Kimura، نويسنده , , Motohiko and Toda، نويسنده , , Mitsuo، نويسنده ,
Abstract :
A new type of dendritic molecules, Gd–DTPA derivatives, which work as a functionalized ligand coordinating gadolinium(III) ion at the center of their frameworks with different terminal moieties on the molecular surfaces, was readily synthesized with high yield. The structures were established by 1H, 13C NMR, and mass spectral studies. In vitro studies showed them to have enhanced r1 value in albumin medium and good potentiality as MRI contrast agent.
Keywords :
Gd-complexes , T1 and r1 values , MRI contrast agents , Dendritic ligands
