Novel polyisoprenylated benzophenone derivatives from Garcinia paucinervis

Four novel polyisoprenylated benzophenone derivatives, paucinones A–D (1–4), were isolated from the leaves of the plant Garcinia paucinervis. Paucinones A–C (1–3) contained an unexpected cyclohexane-spiro-tetrahydrofuran moiety. A 1-methylene-3,3-dimethylcyclohexane group never reported before was found in the structure of paucinone D (4). The structures of these compounds were elucidated with spectroscopic evidences. The relative stereochemistries of 1–4 were determined by NOESY correlations. These compounds showed significant cytotoxicities against HeLa cells.