Author/Authors :
Shigenaga، نويسنده , , Akira and Yamamoto، نويسنده , , Jun and Hirakawa، نويسنده , , Hiroko and Ogura، نويسنده , , Keiji and Maeda، نويسنده , , Nami and Morishita، نويسنده , , Ko and Otaka، نويسنده , , Akira، نويسنده ,
Abstract :
To develop a thiol-responsive DNA-releasing system, a thiol-responsive amino acid capable of inducing an amide bond cleavage in the presence of a thiol was developed. It was successfully combined with peptide nucleic acid (PNA), and thiol-induced release of DNA from the thiol-responsive PNA/DNA complex was observed.
