Determination of the absolute configuration of nodulisporacid A by the concise synthesis of four stereoisomers via three-component reaction and one-pot construction of the framework

Four stereoisomers of nodulisporacid A (1) were synthesized by the concise approach which includes three-component reaction and subsequent one-pot construction of the whole framework. The 1H NMR comparison of the derivatives (10–12) revealed the absolute configuration of natural 1 to be 4R,4′R,6′R.