Title of article
Efficient synthesis of 5-nitro-benzo[b]furans via 2-bromo-4-nitro-phenyl acetates
Author/Authors
Bochicchio، نويسنده , , Antonella and Chiummiento، نويسنده , , Lucia and Funicello، نويسنده , , Maria and Lopardo، نويسنده , , Maria Teresa and Lupattelli، نويسنده , , Paolo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
2824
To page
2827
Abstract
Acetylation/Sonogashira cross-coupling reaction/cyclization has been carried out in one-pot using a Na2PdCl4/2-(di-tert-butylphosphino)-N-phenylindole/CuI system in TMEDA to give 5-nitro-2-substituted benzo[b]furans in excellent yields. We also describe the extension of this method to 4-EWG-2-bromo-phenols obtaining 2,5-disubstituted-benzo[b]furans in good yields.
Keywords
2-Br-phenyl acetates , Sonogashira reaction , Pd catalyst , heteroannulation
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1872206
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