Title of article
Nitrogen ylide-mediated cyclopropanation of lactams and lactones
Author/Authors
Villar، نويسنده , , Irene Suarez del and Gradillas، نويسنده , , Ana and Domيnguez-Romero، نويسنده , , Gema and Pérez-Castells، نويسنده , , Javier، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
3095
To page
3098
Abstract
Cyclopropanation of α,β-unsaturated δ-lactams and δ-lactones mediated by nitrogen ylides is described. The process tolerates different alkyl halides and gives efficiently bicyclo[4.1.0]heptanes in a totally stereoselective manner. On the other hand, ε-lactams under our experimental conditions suffer a novel process involving a skeletal reorganization to give a bicyclic[3.3.0] system.
Keywords
Cyclopropanation , Lactones , lactams , Nitrogen ylides , Rearrangements
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1872274
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